When Paige tries to hire a new professor for the Magic School, one of the candidates, Drake, turns out to be an ex-demon who made a deal with a sorcerer to become human.
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When Inspector Morris believes his friend is possessed, the Charmed Ones investigate and find that a victim of a fire in 1899 has taken control of Mike.
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Piper is attacked by demons and winds up in a coma. As she hovers between life and death, her spirit meets Cole, who says he is trying to help restore Phoebe's faith in love.
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The sisters try to divert Zankou's attention from the Nexus, but Zankou steals Phoebe's power of premonition, enabling him to anticipate and prevent their attacks.
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A young demon (Mykel Shannon) trying to take over the Underworld attempts to lure the Charmed Ones out of hiding, and when Billie stumbles onto his plot, she becomes one of his victims.
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The Charmed Ones help agent Murphy track a demon who escaped from the government's custody and learn that a virus is causing magical beings to run amok.
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When the Angel of Death returns seeking Leo, the Charmed Ones try to use a spell to hide Leo, but it misfires and everyone suddenly looks like Leo.
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About
Charmed chronicles the conflicts and the love among three vastly different sisters and their need to come together to fulfill an ancient witchcraft prophecy.