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Sam and Dean discover a doctor who, back in 1816, became obsessed with finding the secret of eternal life by taking people's vital organs. Meanwhile, Bobby finds Bela and Dean leaves Sam to confront her.
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Sam, Dean, and Bobby hunt down Lilith and fight her and her demons in a final effort to save Dean's life.
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Bobby, Sam, and Dean visit an old friend of Bobby's, a psychic, to help them get some answers as to how and why Dean has returned from Hell.
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Ghosts of children Bobby couldn't save cripple him with guilt and Sam and Dean must save him. However, they must also ignore the spirits of Meg and Agent Hendricksen, who have come back to accuse the brothers of failing them.
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Sam and Dean meet Castiel and his fellow angel Uriel, who warn the brothers to avoid intervening in a town where a witch is attempting to summon the demon Samhain, opening one of the Seals.
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The Winchesters investigate a town wishing well that really grants wishes at a terrible cost.
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Sam, Dean, and Ruby look for Anna who hears the voices of angels. When Ruby seemingly betrays the brothers and leaves with Anna, Sam enlightens Dean on how Ruby saved Sam's life while Dean was in Hell.
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About
Twenty-six years ago, Sam Winchester and Dean Winchester lost their mother to a mysterious and demonic supernatural force. Subsequently, their father John raised them to be soldiers. He taught them about the paranormal evil that lives in the dark corners and on the back roads of America... he taught them how to kill it.